Short Bio

Dr. Xuri Li is a Professor and the Scientific Director of the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Dr. Li graduated from Shanghai Medical University, obtained her Ph.D. from Karolinska Institute in Stockholm, Sweden, and received her postdoctoral training at the Karolinska Institute and the Vesalius Research Center in Leuven University, Belgium. During 2005-2012, Dr. Li served as a Principal Investigator at the National Institutes of Health, National Eye Institute in USA. Dr. Li has published 103 scientific publications (total IF ≥ 1040) and is a referee of 23 international journals. Dr. Li is an inventor of numerous international patents and is the founder of the Asia Pacific Vascular Biology Organization (APVBO).

Major Research Interests

Our team strives to understand the processes of angiogenesis, vasculogenesis and neurogenesis in the eye in development, normal physiology and various pathologies. We hope to use the gained knowledge to explore better therapies for human diseases. Specifically, we characterize the functional properties of important angiogenic and antiangiogenic molecules using animal models, cultured cells and molecular approaches. We also utilize the developing mouse eye as a model to explore the fundamental mechanisms of angiogenesis, vasculargenesis and neurogenesis. Furthermore, we try to reveal the basic cellular and molecular mechanisms underlying our findings.

NIH Intramural Funding as a Principal Investigator

2006                                                              US $1,770,000

2007               1Z01EY000447-01                US $1,774,036

2008               1Z01EY000447-02                US $1,523,283

2009               1ZIAEY000447-03                US $1,347,483

2010               1ZIAEY000447-04                US $1,342,304

2011               1ZIAEY000447-05                US $1,409,461

2012               1ZIAEY000447-06                US $1,047,086

FUNDING IN  CHINA AS  A PRINCIPAL INVESTIGATOR

2013-2017                   1000-Plan Expert, Leading Expert of the Sun Yat-Sen University, Principal Investigator, 12000000 CNY

2014-2018                   NSFC National Key Program, Principal Investigator, 2900000 CNY

2014-2018                   Guangdong Province Leading Expert Program, Principal Investigator, 5000000 CNY

2016-2017                   NSFC China-Sweden International Collaboration Program, Principal Investigator, 240000 CNY

2017-2020                   NSFC grant, Principal Investigator, 540000 CNY

2018-2021                   Guangzhou Science and Development Key Program, Principal Investigator, 2000000 CNY

2019-2022                   Boehringer-Ingelheim innovation research grant, 3628800 CNY

REVIEWED SCIENTIFIC MANUSCRIPTS FOR:

1. Nature Metabolism

2. Nature Protocols

3. Journal of Experimental Medicine

4. Proceedings of the National Academy of Sciences USA

5. Blood

6. Circulation Research

7. Molecular Therapy

8. Biomaterials

9. The FASEB Journal

10. Cancer Letters

11. Gene Therapy

12. Oncogene

13. The Journal of Pathology

14. The American Journal of Pathology

15. Science Advances

16. Aging

17. PLoS ONE

18. Pigment Cell & Melanoma Research

19. Experimental Eye Research

20. Investigative Ophthalmology and Visual Science

21. British Journal of Ophthalmology

22. Journal of Visualized Experiments

23. Journal of Geriatric Cardiology

REVIEWED RESEARCH GRANT FOR:

• Intercellular Interactions Study Section, Center for Scientific Review, NIH, USA

• Atherosclerosis and Inflammation in the Cardiovascular Systems Study Section, Center for Scientific Review, NIH, USA

• The Agency for Science, Technology and Research’s (A*STAR), Biomedical Research Council (BMRC), Singapore

• Ministry of Research and Innovation, Government of Ontario, Canada

• Medical Research Council, Research Councils UK

• American Institute of Biological Sciences (AIBS), USA

• The National Natural Science Foundation of China (NSFC)

Selected Publications

1. Ekstrom T.J., Cui H., Xuri Li, Ohlsson R., Promoter-specific IGF2 imprinting status and its plasticity during human liver development, Development, 121(2):309-316, 1995, PubMed   

2. Xuri Li, Adam G., Cui H., Sandstedtedt B., Ohlsson R., Ekstrom T.J. Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting, Oncogene, 1(2):221-229, 1995, PubMed   

3. Xuri Li, Nong Z., Ekström C., Larsson E., Nordlinder H., Hofmann W. J, Trautwein C., Odenthal M., Dienes H.P., Ekstrom T. J. and Schirmacher P. Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma, Cancer Res, 57(10):2048-2054, 1997, PubMed

4. Xuri Li, Ponten A., Aase K., Linda K., Abramsson A., Uutela M., Backman G., Hellstrom M., Bostrom H., Li H., Betsholtz C., Heldin C. H., Alitalo K., Ostman A. & Eriksson U. PDGF-C is a new protease-activated ligand for the PDGF-a receptor, Nat Cell Biol, 2(5):302-309, 2000 PubMed

   (Featured News & Views: A new member of an old family, Nat Cell Biol, 2(5): E78-79, 2000 PubMed)

5. Bergsten, E., Uutela, M., Xuri Li, Pietras, K., Ostman, A., Heldin, C. H., Alitalo, K., Eriksson, U. PDGF-D is a specific, protease-activated ligand for the PDGF beta-Receptor, Nat Cell Biol, 3(5):515-516, 2001, PubMed

6. Hellstrom, M., Gerhardt, H., Kalen, M., Xuri Li, Eriksson, U., Wolburg, H., Betsholtz, C. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis, J Cell Biol, 153(3):543-554, 2001, PubMed

7. Uutela, M., Lauren, J., Bergsten, E., Xuri Li, Horelli-Kuitunen, N., Eriksson, U., Alitalo, K., Chromosomal location, exon structure, and vascular expression patterns of the human PDGF-C and PDGF-C genes, Circulation, 103(18):2242-2247, 2001, PubMed

8. Aase, K., Von Euler, G., Xuri Li, Ponten, A., Thoren, P., Cao, Y., Olofsson, B., Gebre-Medhin, S., Pekny, M., Alitalo, K., Betsholtz C., Eriksson, U. VEGF-B deficient mice display an atrial conduction defect, Circulation, 104(3):358-364, 2001, PubMed

9. Eitner F., Ostendorf T., Van Roeyen C., Kitahara M., Xuri Li, Aase K., Groene H-J., Eriksson U., Floege J. Expression of a Novel PDGF Isoform, PDGF-C, in Normal and Diseased Rat Kidney, J Am Soc Nephrol, 13(4):910-917, 2002, PubMed

10. Cao, R., Brakenhielm, E., Xuri Li, Pietras K., Widenfalk J., Ostman A., Eriksson, U., Cao, Y. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors, FASEB J, 16(12):1575-1583, 2002, PubMed

11.  Li, H., Karlsson L., Xuri Li, Eriksson, U. PDGF-D is a potent transforming and angiogenic factor, Oncogene, 22(10):1501-1510, 2003, PubMed

12. Ponten A., Xuri Li, Aase K., Thoren P., Sjoblom T., Ostman A. and Eriksson U., Overexpression of PDGF-C in mouse heart induces cardiac fibrosis, hypertrophy and dilated cardiomyopathy, Am J Pathol, 163(2):673-682, 2003, PubMed

13. Fredriksson, L., Li, H., Fieber, C., Xuri Li and Eriksson U., Tissue plasminogen activator is a potent activator of PDGF-CC, EMBO, 23(19):3793-3802, 2004, PubMed

14. Xuri Li, Tjwa, M., Moons, L., Fons, P., Noel, A., Ny, A., Zhou, J. M., Lennartsson, J., Li, H., Luttun, A., Ponten, A., Devy, L., Bouche, A., Oh, H., Manderveld, A., Blacher, S., Communi, D., Savi, P., Bono, F., Dewerchin, M., Foidart, J. M., Autiero, M., Herbert, J. M., Collen, D., Heldin, C. H., Eriksson, U., Carmeliet, P., Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors, J Clin Invest, 115(1):118-127, 2005, PubMed

    JCI Article In The News: PDGF-CC, the best thing ever since sliced bread? J Clin Invest, 115(1), 2005 website

    Featured News: Platelet-derived growth factor CC--a clinically useful angiogenic factor at last?, N Engl J Med, 352(17): 1815-1816, 2005 website

15. Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang, C., Hua, J., Matsuo, O., Fong, G. H., Ding, H., Cao, Y., Becker, K. G., Nash, A., Heldin, C. H., Xuri Li*, VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats, J Clin Invest, 118(3):913–923, 2008, PubMed

16. Xuri Li, Tjwa, M., Van Hove, I., Enholm, B., Neven, E., Paavonen, K., Jeltsch, M., Diez Juan, T., Sievers, R. E., Chorianopoulos, E., Wada, H., Vanwildemeersch, M., Noel, A., Foidart, J. M., Springer, M. L., von Degenfeld, G., Dewerchin, M., Blau, H. M., Alitalo, K., Eriksson, U., Carmeliet, P., Moons, L., Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium, Arterioscler Thromb Vasc Biol, 28(9):1614-1620, 29, 2008, PubMed

17. Anderberg, C., Li, H., Fredriksson, L., Andrae, J., Betsholtz, C., Xuri Li, Eriksson, U., Pietras, K., Paracrine signaling by PDGF-CC promotes tumor growth by recruitment of cancer-associated fibroblasts, Cancer Res, 69(1):369-378, 2009, PubMed

18. Gavard, J., Hou, X., Qu, Y., Masedunskas, A., Weigert, R., Xuri Li, Gutkind, JS., A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability, Mol Cell Biol, 29(9):2469-2480, 2009, PubMed

19. Zhang, F., Tang, Z., Hou, X., Lennartsson, J., Li, Y., Koch, A. W., Scotney, P., Lee, C., Arjunan, P., Dong, L., Kumar, A., Rissanen, T. T., Wang, B., Nagai, N., Fons, P., Fariss, R., Zhang, Y., Wawrousek, E., Tansey, G., Raber, J., Fong, G. H., Ding, H., Greenberg, D. A., Becker, K. G., Herbert, J. M., Nash, A., Yla-Herttuala, S., Watts, R. J., Xuri Li*, VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis, Proc Natl Acad Sci USA, 106(15):6152-6157, 2009, PubMed

20. Tang, Z., Arjunan, P., Lee, C., Li, Y., Kumar, A., Hou, X., Wang, B., Wardega, P., Zhang, F., Dong, L., Zhang, Y., Zhang, S. Z., Ding, H., Fariss, R. N., Becker, K. G., Lennartsson, J., Nagai, N., Cao, Y., Xuri Li*, Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation, J Exp Med, 207(4):867-880, 2010, PubMed

21. Kumar, A., Hou, X., Lee, C., Li, Y., Maminishkis, A., Tang, Z., Zhang, F., Langer, H. F., Arjunan, P., Dong, L., Wu, Z., Zhu, L. Y., Wang, L., Min, W., Colosi, P., Chavakis, T., Xuri Li*, PDGF-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase 3 beta (GSK3{beta}) phosphorylation, J Biol Chem, 285(20):15500-15510, 2010, PubMed

    Cover image for J Biol Chem, 285(20), 2010 website

22. Sakurai, A., Gavard, J., Annas-Linhares, Y., Basile, J. R., Amornphimoltham, P., Palmby, T. R., Yagi, H., Zhang, F., Randazzo, P. A., Xuri Li, Weigert, R., Gutkind, J. S., Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras, Mol Cell Biol, 30(12):3086-98, 2010, PubMed

23. Hou, X., Kumar, A., Lee, C., Wang, B., Arjunan, P., Dong, L., Maminishkis, A., Tang, T., Li, Y., Zhang, F., Zhang, S-Z., Wardega, P., Chakrabarty, S., Liu, B., Wu, Z., Colosi, P., Fariss, R. N., Lennartsson, J., Nussenblatt, R., Gutkind, J. S., Cao, Y., Xuri Li*, PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets, Proc Natl Acad Sci USA, 107(27):12216-12221, 2010, PubMed

24. Narazaki, M., Segarra, M., Hou, X., Tanaka, T., Xuri Li, Tosato, G., Oligo-guanosinenucleotide induces Neuropilin-1 internalization in endothelial cells and inhibits angiogenesis, Blood, 116(16):3099-3107, 2010, PubMed

25. Langer, H. L., Chung, K-J., Orlova, V. V., Choi, E. Y., Kaul, S., Kruhlak, M. J., Alatsatianos, M., DeAngelis, R. A., Roche, P. A., Magotti, P., Xuri Li, Economopoulou, M., Rafail, S., Lambris, J. D., Chavakis, T., Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis, Blood, 116(22):4395-4403, 2010, PubMed

26. Xuri Li*, VEGF-B: a thing of beauty, Cell Res, 20(7): 741-744, 2010, PubMed

27. Langer, H. F., Choi, E. Y., Zhou, H., Schleicher, R., Chung, K. J., Tang, Z., Gobel, K., Bdeir, K., Chatzigeorgiou, A., Wong, C., Bhatia, S., Kruhlak, M. J., Rose, J. W., Burns, J. B., Hill, K. E., Qu, H., Zhang, Y., Lehrmann, E., Becker, K. G., Wang, Y., Simon, D. I., Nieswandt, B., Lambris, J. D., Xuri Li, Meuth, S. G., Kubes, P., Chavakis, T., Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis, 110(9):1202-1210, Circ Res, 2012, PubMed

28. Zhang, F., Li, Y., Tang, Z., Kumar, A., Lee, C., Zhang, L., Zhu, C., Ameln, A. K., Wang, B., Gao, Z., Zhang, S., Langer, H., Hou, X., Jensen, L., Ma, W., Wong, W., Chavakis, T., Liu, Y., Cao, Y., Xuri Li*, Proliferative and survival effects of PUMA promotes angiogenesis, 2(5):1272-1285, Cell Reports, 2012, PubMed     

    Biomedical Picture of the Day: Double Agent PUMA, Website

29. Segarra, M., Ohnuki, H., Maric, D., Salvucci, O., Hou, X., Xuri Li, and Tosato, G., Semaphorin 6A regulates angiogenesis by modulating VEGF signaling, Blood, 120(19):4104-4115, 2012, PubMed

30. Xuri Li*, Kumar, A., Zhang, F., Lee, C., Tang, Z., Complicated life, complicated VEGF-B, Trends Mol Med, 18(2):119–127, 2012, PubMed

    Cover image for Trends in Molecular Medicine, 18(2), 2012, Website

31. Hosaka, K., Yang, Y., Seki, T., Nakamura, M., Andersson, P., Rouhi, P., Yang, X., Jensen, L., Lim, S., Feng, N., Xue, Y., Xuri Li, Larsson, O., Ohhashi, T., Cao, Y., Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis, Nat Commun, 4:2129, 2013, PubMed

32. Dong, M., Yang, X., Lim, S., Cao, Z., Honek, J., Lu, H., Zhang, C., Seki, T., Hosaka, K., Wahlberg, E., Yang, J., Zhang, L., Lanne, T., Sun, B., Xuri Li, Liu, Y., Zhang, Y., Cao, Y., Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent Lipolysis, Cell Metab, 18(1):118-129. 2013, PubMed

33. Lee, C., Zhang, F., Tang, Z., Liu, Y., Xuri Li*, PDGF-C: a new performer in the neurovascular interplay, Trends Mol Med, 19(8):474-86, 2013, PubMed

34. Huang, Y., Hoffman, C., Rajappa, P., Kim, J. H., Hu, W., Huse, J. T., Tang, Z., Xuri Li, Weksler, B., Bromberg, J., Lyden, D., Greenfield, J. P., Oligodendrocyte progenitor cells promote neovascularization in glioma by disrupting the blood-brain barrier, Cancer Res, 74(4):1011-1021, 2014, PubMed

35. He, C., Zhao, C., Kumar, A., Lee, C., Chen, M., Huang, L., Wang, J., Ren, X., Jiang, Y., Chen, W., Wang, B., Gao, Z., Zhong, Z., Huang, Z., Zhang, F., Huang, B., Ding, H., Ju, R., Tang, Z., Liu, Y., Cao, Y., Xuri Li*., Liu, X*., Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration, Proc Natl Acad Sci U S A, 111(41):14806-11, 2014, PubMed

36. Salvucci, O., Ohnuki, H., Maric, D., Hou, X., Xuri Li, Yoon, S. O., Segarra, M., Eberhart, C. G., Acker-Palmer, A., Tosato, G., EphrinB2 controls vessel pruning through STAT1-JNK3 signalling, Nat Commun, 6:6576, 2015, PubMed

37.  R. I. Schleicher, F. Reichenbach, P. Kraft, A. Kumar, M. Leskan, F. Todt, K. Goebel, T. Geisler, A. Bauer, S. Wesselborg, L. O’Reilly, S. G. Meuth, K. Schulze-Osthoff, M. Gawaz, Xuri Li, C. Kleinschnitz, F. Edlich, H. Langer, Platelets induce apoptosis via membrane-bound FasL, Blood, 126(12):1483-1493, 2015, PubMed

38. L D. Jensena, M Nakamuraa, L Bräutigamc, Xuri Li, Y Liu, N J. Samanie, and Y Cao, VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish, Proc Natl Acad Sci U S A, 12(44):E5944-53, 2015, PubMed

39. Lin, H., Ouyang, H., Zhu, J., Huang, S., Liu, Z., Chen, S., Cao, G., Li, G., Signer, R. A., Xu, Y., Chung, C., Zhang, Y., Lin, D., Patel, S., Wu, F., Cai, H., Hou, J., Wen, C., Jafari, M., Liu, X., Luo, L., Qiu, A., Hou, R., Chen, B., Chen, J., Granet, D., Heichel, C., Shang, F., Xuri Li, Krawczyk, M., Skowronska-Krawczyk, D., Wang, Y., Shi, W., Chen, D., Zhong, Z., Zhong, S., Zhang, L., Morrison, S. J., Maas, R. L., Zhang, K., Liu, Y., Lens regeneration using endogenous stem cells with gain of visual function, Nature, 351(7594):323-328, 2016, PubMed

40. Seki, T., Hosaka, K., Lim, S., Fischer, C., Honek, J., Yang, Y., Andersson, P., Nakamura, M., Naslund, E., Yla-Herttuala, S., Sun, M., Iwamoto, H., Xuri Li, Liu, Y., Samani, N. J., Cao, Y., Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat, Nat Commun, 7:12152, 2016, PubMed

41. Jiang, Y., Lin, X., Tang, Z., Lee, C., Tian, G., Du, Y., Yin, X., Ren, X., Huang, L., Ye, Z., Chen, W., Zhang, F., Mi, J., Gao, Z., Wang, S., Chen, Q., Xing, L., B. Wang, Y. Cao, W. C. Sessa, R. Ju*, Y. Liu*, Xuri Li*, Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK, Proc Natl Acad Sci U S A, 114(40): 10737-10742, 2017, PubMed

42. Weisi Lu, Xuri Li*, Vascular stem/progenitor cells: functions and signaling pathways, Cell Mol Life Sci, 75(5):859-869, 2017, PubMed

43. Xuri Li*, Carmeliet, P.*, Targeting angiogenic metabolism in disease, Science, 359(6382):1335-1336, 2018, PubMed

44. Chunsik Lee, Xuri Li*, Platelet-derived growth factor-C and -D in the cardiovascular system and diseases, Molecular Aspects of Medicine, 62:12-21, 2018, PubMed

45. Weisi Lu, Xuri Li*, PDGFs and their receptors in vascular stem/progenitor cells: Functions and therapeutic potential in retinal vasculopathy, Molecular Aspects of Medicine, 62:22-32, 2018, PubMed

46. Anil Kumar, Xuri Li*, PDGF-C and PDGF-D in ocular diseases, Molecular Aspects of Medicine, 62:33-43, 2018, PubMed

47. S. Vandekeere, C. Dubois, J. Kalucka, M. R. Sullivan, M. Gar-cía-Caballero, J. Goveia, R.  Chen, F. F. Diehl, Libat Bar-Lev, J. Souffreau, A. Pircher, S. Kumar, S. Vinckier, Y. Hirabayashi, S-g. Furuya, L. Schoonjans, G. Eelen, B. Ghesquière, E. Keshet, Xuri Li*, M. G. V. Heiden, M. Dewerchin*, & P. Carmeliet*, Serine synthesis via PHGDH is essential for heme production in endothelial cells, Cell Metabolism, 28(4):573-587, 2018, PubMed

48. Bruning, U., Morales-Rodriguez, F., Kalucka, J.Goveia, J., Taverna, F., Queiroz, K. C. S., Dubois, C., Cantelmo, A. R., Chen, R., Loroch, S., Timmerman, E., Caixeta, V.Bloch, K., Conradi, L. C., Treps, L., Staes, A., Gevaert, K., Tee, A., Dewerchin, M., , Semenkovich, C. F., Impens, F., Schilling, B., Verdin, E., Swinnen, J. V., Meier, J. L., Kulkarni, R. A., Sickmann, A., Ghesquiere, B., Schoonjans, L., Xuri Li*, Mazzone, M., Carmeliet, P.*, Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation, Cell Metabolism, 28(6):866-880, 2018, PubMed

49. Kalucka, J., Bierhansl, L., Conchinha, N. V., Missiaen, R., Elia, I., Bruning, U., Scheinok, S., Treps, L., Cantelmo, A. R., Dubois, C., de Zeeuw, P., Goveia, J., Zecchin, A., Taverna, F., Morales-Rodriguez, F., Brajic, A., Conradi, L. C., Schoors, S., Harjes, U., Vriens, K., Pilz, G. A., Chen, R., Cubbon, R., Thienpont, B., Cruys, B., Wong, B. W., Ghesquiere, B., Dewerchin, M., De Bock, K., Sagaert, X., Jessberger, S., Jones, E. A. V., Gallez, B., Lambrechts, D., Mazzone, M., Eelen, G., Xuri Li*, Fendt, S. M., Carmeliet, P.*, Quiescent Endothelial Cells Upregulate Fatty Acid beta-Oxidation for Vasculoprotection via Redox Homeostasis, Cell Metabolism, 28(6):881-894, 2018, PubMed

50. Eelen, G., Dubois, C., Cantelmo, A. R., Goveia, J., Bruning, U., DeRan, M., Jarugumilli, G., van Rijssel, J., Saladino, G., Comitani, F., Zecchin, A., Rocha, S., Chen, R., Huang, H., Vandekeere, S., Kalucka, J., Lange, C., Morales-Rodriguez, F., Cruys, B., Treps, L., Ramer, L., Vinckier, S., Brepoels, K., Wyns, S., Souffreau, J., Schoonjans, L., Lamers, W. H., Wu, Y., Haustraete, J., Hofkens, J., Liekens, S., Cubbon, R., Ghesquiere, B., Dewerchin, M., Gervasio, F. L., Xuri Li*, van Buul, J. D., Wu, X., & Carmeliet, P.*, Role of glutamine synthetase in angiogenesis beyond glutamine synthesis, Nature, 561(7721):63-69, 2018, PubMed

51. Arjunan, P., Lin, X., Tang, Z., Du, Y., Kumar, A., Liu, L., Yin, X., Huang, L., Chen, W., Chen, Q., Ye, Z., Wang, S., Kuang, H., Zhou, L., Xu, K., Chen, X., Zeng, H., Lu, W., Cao, Y., Liu, Y., Zhao, C.*, Xuri Li*, VEGF-B is a potent antioxidant, Proc Natl Acad Sci U S A, 115(41): 10351-10356, 2018, PubMed

52. Metabolic pathways fueling the endothelial cell drive, Xuri Li*, Anil Kumar, & Peter Carmeliet*, Annual Reviews of Physiology, 81:483-503, 2019, PubMed

53. EndoDB: a database of endothelial cell transcriptomics data, Khan, S., Taverna, F., Rohlenova, K., Treps, L., Geldhof, V., de Rooij, L., Sokol, L., Pircher, A., Conradi, L. C., Kalucka, J., Schoonjans, L., Eelen, G., Dewerchin, M., Karakach, T., Xuri Li*, Goveia, J., Carmeliet, P.*, Nucleic Acids Res, 47(D1): D736-D744, 2019, PubMed

54. Hallmarks of Endothelial Cell Metabolism in Health and Disease, Cell Metabolism, Xuri Li*, Sun, X., Carmeliet, P.*, 30:414-433, 2019, PubMed

55. An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates, Goveia, J., Rohlenova, K., Taverna, F., Treps, L., Conradi, L. C., Pircher, A., Geldhof, V., de Rooij, Lpmh, Kalucka, J., Sokol, L., Garcia-Caballero, M., Zheng, Y., Qian, J., Teuwen, L. A., Khan, S., Boeckx, B., Wauters, E., Decaluwe, H., De Leyn, P., Vansteenkiste, J., Weynand, B., Sagaert, X., Verbeken, E., Wolthuis, A., Topal, B., Everaert, W., Bohnenberger, H., Emmert, A., Panovska, D., De Smet, F., Staal, F. J. T., McLaughlin, R. J., Impens, F., Lagani, V., Vinckier, S., Mazzone, M., Schoonjans, L., Dewerchin, M., Eelen, G., Karakach, T. K., Yang, H., Wang, J., Bolund, L., Lin, L., Thienpont, B., Xuri Li*, Lambrechts, D., Luo, Y., Carmeliet, P.*, Cancer Cell, 37(1): 21-36 e13, Jan., 2020, PubMed

56. Single-Cell Transcriptome Atlas of Murine Endothelial Cells, Kalucka, J., de Rooij, Lpmh, Goveia, J., Rohlenova, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L. A., Veys, K., Garcı´a-Caballero, M., Khan, S., Geldhof, V., Sokol, L., Chen, R., Treps, L., Borri, M., de Zeeuw, P., Dubois,C., Karakach, T. K., Falkenberg, K. D., Parys, M., Yin, X., Vinckier, S., Du, Y., Fenton, R. A., Schoonjans, L., Dewerchin, M., Eelen, G., Thienpont, B., Lin, L., Bolund, L., Xuri Li*, Luo, Y.,* & Carmeliet, P.*, Cell, 180(4): 764-779 e20, 2020, PubMed

57. Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis, Rohlenova, K., Goveia, J., Garcia-Caballero, M., Subramanian, A., Kalucka, J., Treps, L., Falkenberg, K. D., de Rooij, Lpmh, Zheng, Y., Lin, L., Sokol, L., Teuwen, L. A., Geldhof, V., Taverna, F., Pircher, A., Conradi, L. C., Khan, S., Stegen, S., Panovska, D., De Smet, F., Staal, F. J. T., McLaughlin, R. J., Vinckier, S., Van Bergen, T., Ectors, N., De Haes, P., Wang, J., Bolund, L., Schoonjans, L., Karakach, T. K., Yang, H., Carmeliet, G., Liu, Y., Thienpont, B., Dewerchin, M., Eelen, G., Xuri Li*, Luo, Y.,* & Carmeliet, P.*, Cell Metab, 31(4): 862-877 e14, April, 2020, PubMed

58. Eelen, G., Treps, L., Xuri Li, Carmeliet, P., Basic and Therapeutic Aspects of Angiogenesis Updated." Circ Res, 127(2): 310-329, 2020, PubMed

59. Weisi Lu*, Yunling Xie1, Binjie Huang1, Tenghui Ma, Huaiming Wang, Boxion Deng, Shaomin Zou, Wencong Wang, Qin Tang, Ziqing Yang, Xuri Li*, Lei Wang, Lekun Fang*, Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy, Sci Transl Med, 13, eabc2344, 24 February 2021, PubMed

60. S. J. Dumas, E. Meta, M. Borri, Y. Luo, Xuri Li*, T. J. Rabelink*, P. Carmeliet*, Phenotypic diversity and metabolic specialization of renal endothelial cells, Nature Reviews Nephrology, March 25, 2021, PubMed

Book Chapters

1. Eriksson, U., Li, X. Chapter: Vascular Endothelial Growth Factor B (VEGF-B),Encyclopedia of Hormones, edited by Henry, HL & Norman, AW, Elsevier Science, Academic press, 2003

2. Li, X.*, Kumar, A., Lee, C., Tang, Z., Li, Y., Arjunan, P., Hou, X., Zhang, F., Can VEGF-B be used to treat neurodegenerative diseases? Neurodegenerative Diseases - Book 1, ISBN 979-953-307-041-3, InTech, Open Access Publisher, 2011

3. Ju, R., Lee, C., Lu, W., Li, X*., Fibroblast Growth Factors: Biology and Clinical Application, Growth Factors in the Eye, ISBN: 978-981-3143-36-4, World Scientific, 2017

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